NAD + supports the recovery of cognitive functions, strengthens the immune system, is a strong antioxidant. It acts as a coenzyme in some biochemical reactions. It is necessary for their proper course, among others transfers electrons between them.
A common symptom among people with MS and other neurological diseases is a mental reluctance to undertake any activity, it may be caused by low levels of NAD + in the body. The high concentration of NAD + delays the feeling of fatigue caused by intense training or rehabilitation.
NAD + activates sirtuins, which are responsible for the long-lasting, efficient functioning of organs in the body, and thus affects good physical condition. Clearing metabolic pathways through the increase of NAD + along with the activation of sirtuins increases the sensible energy, which is directed both to the nervous system and to the muscles performing the work.
Higher NAD + expression reduces the toxicity of betaamyloid, which is associated with the pathogenesis of Alzheimer’s disease. NAD + is also responsible for the regulation of inflammation in the nervous system, influencing the release of inflammatory cytokines by microglia. As a result, NAD + reduces the risk of degenerative diseases.
NAD + influences the formation of TH1 and TH17 cytokines of the immune system. These cytokines are involved in the pathogenesis of many autoimmune diseases. NAD + not only inhibits but also reverses neuronal degeneration through immunosuppression caused by an increase in IL10 and accelerated myelination. It is proven that glial cells deliver NAD to neurons in stressful situations. In multiple sclerosis, microglia levels of NAD + have been found to be disturbed, resulting in an increase in the production of pro-inflammatory cytokines that induce neurodegeneration.
In patients with MS, NAD levels increase in the immune system and decrease in the nervous system, causing a deficiency in neurons which are in turn more susceptible to damage during the disease.
